The “maquila” assembly plant is the most important economic activity in the city, because of its location many US industries use Mexican cheap labor and qualified work force to assembly their products. However this is changing and other economic branches are growing more than the industrial sector, such as services and commerce.

Nogales is diversifying its economy, which is a very good sign for the future.

Another main activity is the commerce of arts and crafts, where the tourist may purchase classic souvenirs or "curios" with a wide variety of crafts shops to choose from. Tourists may also enjoy the great services in restaurants and hotels.